一、基本信息

陈张帆，女，1985年1月，研究生/博士，副研究员，上海海洋大学硕导、江苏海洋大学硕导。研究方向：鱼类种质资源保存及重要性状分子机制解析。

主要围绕鱼类种质保存、抗病免疫与性别生长二态性遗传解析与基因编辑水产品安全评价方向开展研究。系统优化施氏鲟精子冷冻保存技术，从细胞器结构和能量代谢层面解析精子低温损伤机制，挖掘耐冻性评估分子标记，丰富鱼类低温生物学理论；解析半滑舌鳎、斑石鲷抗弧菌病免疫调控机制与半滑舌鳎雌性发育相关转录调控网络，深化鱼类先天免疫及性别生长二态性认知，支撑抗病良种培育；建立基因编辑半滑舌鳎分子表型、品质及生态适应性多维度安全评价技术体系，填补基因编辑海水鱼安全评估技术空白，为其产业化应用提供技术支撑。主持国家自然科学基金面上项目、国家农业生物育种专项子课题、国家重点研发计划子课题、横向课题各1项。获批基因编辑半滑舌鳎中间试验备案 3 项；发表论文50篇，其中以第一作者或共同通讯作者发表15篇；获2022年中国水产学会优秀科技论文，2023年“水科英才”拔尖人才。

联系电话/邮箱：18562565985，chenzf@ysfri.ac.cn

二、代表性文章（8篇以内）

1.Chen Zhangfan, Wu Yinqi, Ding Lanqing, Li Pengfei, Wang Mengqi, Yan Xu, Cheng Fangzhou, Jiang He, Cui Zhongkai, Chen Songlin. Evaluation of an infertile, all-male ZZ line exhibiting female-like growth in Chinese tongue sole (Cynoglossus semilaevis): Growth performance, flesh quality, and muscle metabolome. Biology (Basel). 2026. 15(1):93.

2.Zhang Kali#, Chen Zhangfan#, Gao Chengbin, Li Xihong, Wang Na, Zhang Min, Yan Haipeng, Sha Zhenxia, Chen Songlin. Genome-wide identification and expression analysis of zona pellucida (ZP) gene family in Cynoglossus semilaevis. International Journal of Molecular Sciences. 2025. 26: 5346.

3.Chen ZhangFan, Li Xihong, Cheng Peng, Mai Jiaqi, Sun Yuqi, Wang Jiacheng, Shi Rui, Zhang Qi, Wang Na, Chen Songlin. Characterization of emopamil binding protein (Cs-ebp) reveals its potential role in cholesterol biosynthesis and growth performance of Chinese tongue sole. Aquaculture. 2024. 581: 740382.

4.Wang Jie#, Chen Zhang-Fan#, Xu Wengteng, Li Yangzhen, Lu Sheng, Wang Lei, Song Yu, Wang Na, Gong Lihong, Yang Qian, Chen Songlin. Transcriptomic analysis reveals the gene expression profiles in the spleen of spotted knifejaw (Oplegnathus punctatus) infected by Vibrio harveyi. Developmental and Comparative Immunology. 2022. 133: 104432. #为共同第一作者.

5.Chen Zhang-Fan, Wang Lei, Xu Xiwen, Zhou Qian, Wang Jie, Chen Yadong, Wang Na, Gong Zhihong, Chen Songlin. Molecular cloning and immune characterization of CIITA in artificially challenged Chinese tongue sole (Cynoglossus semilaevis) with Vibrio harveyi. Developmental and Comparative Immunology. 2021. 121: 104091.

6.Chen Zhangfan, Xu Xiwen, Wang Jie, Zhou Qian, Chen Songlin. A genome-wide survey of NOD-like receptors in Chinese tongue sole (Cynoglossus semilaevis): Identification, characterization and expression analysis in response to bacterial infection. Journal of Fish Biology. 2021. 1-12

7.Wang Jie, Chen Yadong, Song Yu, Xu Wenteng, Li Wensheng, Ma Wenhui, Yang Chuanjun, Chen Zhangfan*, Chen Songlin*. Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR/NFkB pathway. Fish and Shellfish Immunology. 2024. 154: 109958.*为共同通讯作者.

8.Wang Jie, Chen Zhang-Fan*, Li Ming, Zhang Ziwei, Song Yu, Xu Wenteng, Wang Lei, Chen Songlin*. Genome-wide identification, immune response profile and functional characterization of IL-10 from spotted knifejaw (Oplegnathus punctatus) during host defense against bacterial and viral infection. Fish and Shellfish Immunology. 2022. 124: 513-524. *为共同通讯作者.

三、其他代表性成果（选填，8项以内）

1. 2022年，半滑舌鳎和斑石鲷分子育种技术创建及新品种创制与应用，范蠡科学技术奖特等奖，11/20

2. 2025年，几种重要养殖鱼类抗病生长性状精准育种技术建立与良种创制，神农中华农业科技奖一等奖，16/20

3. 周茜，陈松林，陈张帆，马欣然，李仰真.一种半滑舌鳎CHST12蛋白及其在抗菌中的应用,发明专利，ZL202210580670.X,2023年6月23日授权。